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Overview

Omicsoft is the leading provider of Next Generation Sequencing, Cancer Genomics, Immunology, and Bioinformatics solutions for Next Generation Sequencing Data and Gene Expression Analysis.

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Keeping you up-to-date with the latest in NGS, Bioinformatics Analysis, and cancer genomics with blogs on Array Suite, OncoLand (TCGA and more), ImmunoLand, and more.

[NEW FEATURE] LAND FUSION GENOME BROWSER: SIDE BY SIDE FUSION BROWSER BY ONE CLICK

Vivian Zhang

Fusion genes are genes that made by joining parts of two different genes, caused by chromosome translocations, inversions and deletions. Fusion genes can play an important role in cancer mutations that have multiple effects on a target gene. At Omicsoft, we provide a powerful fusion detection algorithm in FusionMap. Recently, we implemented a new Fusion Genome Browser view in our "Lands", like OncoLand,  to provide dynamic fusion visualization.

"Fusion Negative Exon Coverage" shows the exon coverage for samples without fusion. "Fusion Positive Exon Coverage" shows the exon coverage for samples with fusion. Each circle represents each fusion ID. By clicking one circle, the corresponding fusion in the other gene panel will also be highlighted. Fusion details will show in the detail window.

"Fusion Negative Exon Coverage" shows the exon coverage for samples without fusion. "Fusion Positive Exon Coverage" shows the exon coverage for samples with fusion. Each circle represents each fusion ID. By clicking one circle, the corresponding fusion in the other gene panel will also be highlighted. Fusion details will show in the detail window.

The example genome browser above clearly shows the 3 prime end of FGFR3 has less coverage in fusion positive samples in comparison with those in fusion negative samples, due to the fusion with TACC3.

The Fusion Genome Browser view is interactive and filterable, by fusion information or by sample Meta Data and Clinical Data, along with other hundreds of annotations: