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Overview

Omicsoft is the leading provider of Next Generation Sequencing, Cancer Genomics, Immunology, and Bioinformatics solutions for Next Generation Sequencing Data and Gene Expression Analysis.

Exciting Updates and Latest News

Keeping you up-to-date with the latest in NGS, Bioinformatics Analysis, and cancer genomics with blogs on Array Suite, OncoLand (TCGA and more), ImmunoLand, and more.

[Land Tutorial] DiseaseLand (ImmunoLand And CVMLand) Comparison Views

Vivian Zhang

 DiseaseLand features Comparison Views, allowing users to easily search and visualize statistical contrasts between groups of samples using common queries: Treated vs Control, Disease vs Normal, Responder vs Non-Responder etc. By searching a gene, the user can visualize the association with comparisons across thousands of projects, and narrow down to find interesting projects interactively. (Additional reading: ComparisonLand ). In this article, we will introduce you on how to use comparison views.

Video Tutorial: Comparison

Comparison Distribution by comparison types:

Comparison distribution by comparison type. Statistics from previous Land version. Actually distribution and number of comparison update quarterly. 

Comparison distribution by comparison type. Statistics from previous Land version. Actually distribution and number of comparison update quarterly. 

 

Search gene and view comparisons:

In DiseaseLand, you can search for a gene and view its expression in all samples or a single project, or you can visualize which comparisons detected up- or down-regulation of the gene. This way, you can identify projects of interest, and discover trends in your favorite gene's regulation.

 

Comparison details for Serpinb 7 by treatment vs. control. By selecting the comparisons (dots) of interest, detailed information will pop up.

Comparison details for Serpinb 7 by treatment vs. control. By selecting the comparisons (dots) of interest, detailed information will pop up.

Comparison Details Views:

Omicsoft uses manually curated metadata to generate statistical tests (called comparisons) for each project/study included in DiseaseLand, generally following the comparisons in the original paper. The Comparison collection is useful for finding the common differential expression patterns/signatures between studies, such as between an microarray and NGS study, or to find links between a gene knockout experiment and a compound treatment study.

When searching for project(s), a few views are available:

Here are a couple example views:

Example Volcano Plot of project GSE38713.

Example Volcano Plot of project GSE38713.

Example Venn Diagram of project GSE14905.

Example Venn Diagram of project GSE14905.

Example Significant Genes of project GSE58121, GSE63980 and GSE63980.

Example Significant Genes of project GSE58121, GSE63980 and GSE63980.