DiseaseLand features Comparison Views, allowing users to easily search and visualize statistical contrasts between groups of samples using common queries: Treated vs Control, Disease vs Normal, Responder vs Non-Responder etc. By searching a gene, the user can visualize the association with comparisons across thousands of projects, and narrow down to find interesting projects interactively. (Additional reading: ComparisonLand ). In this article, we will introduce you on how to use comparison views.
Video Tutorial: Comparison
Comparison Distribution by comparison types:
Search gene and view comparisons:
In DiseaseLand, you can search for a gene and view its expression in all samples or a single project, or you can visualize which comparisons detected up- or down-regulation of the gene. This way, you can identify projects of interest, and discover trends in your favorite gene's regulation.
Comparison Details Views:
Omicsoft uses manually curated metadata to generate statistical tests (called comparisons) for each project/study included in DiseaseLand, generally following the comparisons in the original paper. The Comparison collection is useful for finding the common differential expression patterns/signatures between studies, such as between an microarray and NGS study, or to find links between a gene knockout experiment and a compound treatment study.
When searching for project(s), a few views are available:
Here are a couple example views: