Last time, we introduced some of the basic views in DiseaseLand. In this article, we would like to introduce you to some advanced functionality: SampleSets and GeneSets.
The SampleSet is powerful concept/tool that allow users to create custom sample groupings, based on data in the Land or imported tables. This video tutorial demonstrates several ways to build a SampleSet from data using selection and filters, then uses SampleSets in Land Analytics to scan the entire DiseaseLand to discover differential splicing.
With the newly created sampleset, users can visualize isoform differential expression at the transcript level in the Genome Browser:
Besides the SampleSet tool, GeneSets are a powerful tool for grouping and comparing genes, including members of a gene family, a pathway, or co-regulated genes. These GeneSets can be used to discover DiseaseLand studies that share "genetic signatures" of common up- or down-regulated genes with your GeneSet.
With the created geneset, users can visualize and perform analyses on the set of genes.
Stay tuned for a DiseaseLand comparison views tutorial!