Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 ‘Slicer’ independent and can be mediated by Ago1
Timothy A. Vickers, Walt F. Lima, Hongjiang Wu, Josh G. Nichols, Peter S. Linsley, and Stanley T. Crooke
Nucleic Acids Res. 2009 November; 37(20): 6927–6941. Published online 2009 November. doi: 10.1093/nar/gkp735.